- Clb1 Clb2 Mutants
- clb1∆ clb2∆
- CLB1 clb2∆
- CLB1 clb2∆ cdh1∆
- CLB1 clb2∆ pds1∆
- TAB6-1 CLB1 clb2∆
- CLB2-db∆
- CLB2-db∆ in galactose
- CLB2-db∆ multicopy SIC1
- CLB2-db∆ GAL-SIC1
- CLB2-db∆ multicopy CDC6
- CLB2-db∆ GAL-CDC6
- CLB2-db∆ clb5∆
- CLB2-db∆ clb5∆ in galactose
- GAL-CLB2
- Multicopy GAL-CLB2
- GAL-CLB2 sic1∆
- GAL-CLB2 cdh1∆
- APC-A GAL-CLB2
- swi5∆ GAL-CLB2
- cln1∆ cln2∆ cln3∆ GAL-CLB2
- GAL-CLB2-db∆
CLB2-db∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: kdb2p=0, kdb2"=0.03 (=7.5% activity left due to KEN box).
Length of G1 phase: 34.6 min.
Arrest: Telophase arrest.
Experiments:
Pfleger, C.M. and Kirschner, M.W. (2000). The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14:655-665.
[Abstract] [Article]
[Abstract] [Article]
Wasch, R. and Cross, F. (2002). APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418:556-562.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Wasch, Fig. 2, telophase arrest.
Comments:
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